Open AccessSingle-amplicon MSH2 A636P Mutation Testing in Ashkenazi Jewish Patients With Colorectal Cancer
Author(s) -
José G. Guillem,
Emily Glogowski,
Harvey G. Moore,
Khédoudja Nafa,
Arnold J. Markowitz,
Jinru Shia,
Kenneth Offit,
Nathan A. Ellis
Publication year - 2007
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/01.sla.0000252589.26244.d4
Subject(s) - medicine , colorectal cancer , amplicon , msh2 , mutation , oncology , genetics , gynecology , cancer , dna mismatch repair , polymerase chain reaction , gene , biology
This study summarizes our initial experience with prospective, single-amplicon (mutation-specific) A636P testing in Ashkenazi Jewish patients at risk for Hereditary Nonpolyposis Colorectal Cancer (HNPCC).