Open AccessMaxillary Sinus Augmentation Using a Synthetic Cell-Binding Peptide: A Histologic and Transmission Electron Microscopy Case Study in Man
Author(s) -
Marco Degidi,
Antonio Scarano,
Giovanna Iezzi,
Giovanna Orsini,
Vittoria Perrotti,
R. Strocchi,
Adriano Piattelli
Publication year - 2005
Publication title -
implant dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.538
H-Index - 65
eISSN - 1538-2982
pISSN - 1056-6163
DOI - 10.1097/01.id.0000188471.49933.f2
Subject(s) - osteoid , transmission electron microscopy , maxillary sinus , electron microscope , materials science , biomaterial , matrix (chemical analysis) , microscopy , bone matrix , anatomy , pathology , biomedical engineering , chemistry , medicine , nanotechnology , composite material , cartilage , optics , physics
PepGen P-15 is a combination natural anorganic bovine-derived hydroxyapatite matrix coupled with a synthetic cell-binding peptide (P-15). This material has improved bone formation in periodontal osseous defects and bone regenerative procedures. There were 3 specimens retrieved 18 months after a sinus lifting procedure using PepGen P-15. These specimens were treated to be observed under light microscopy and transmission electron microscopy. Light microscopy showed that most of the particles were surrounded by newly formed bone. In some areas, osteoid matrix was present. No acute inflammatory infiltrate was present. In transmission electron microscopy, all phases of bone formation (i.e., osteoid matrix, woven bone, and lamellar bone) were observed in the newly formed bone around the biomaterial particles. In some regions, this newly formed bone seemed to present interdigitations connecting to or entering into the particle surface. To our knowledge, this is the first report presenting data on transmission electron microscopy of PepGen P-15 used in a sinus augmentation procedure in man. Our results confirm previous reports on the clinical effectiveness of this material.