English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

pletion of lymphoid tissue and a peripheral blood lytnphopenia, as well as an impairment of the animal's immunologic capacity.' Restoration to normal lymphoid histology and immunologic function can be accomplished in several ways. Thymic grafts placed subcutaneously within the first seven days of life have proved effective.2 Massive inocula of thymus cells have been shown to restore these animals.' However, reconstitution is more readily accomplished with inocula of viable spleen cells.4 Osoba and Miller5 have shown that an immunologic recovery can be accomplished when neonatally thymectomized mice are implanted at 7 days of age with diffusion chambers containing newborn and embryonic thymus. The histologic re- covery in many of these animals was incomplete. The tissue in the chambers was shown by these authors to be composed of epithelial reticular cells only when the animals were sacrificed at 10 weeks of age. These studies were interpreted as evidence that a humoral factor liberated by these cells was responsible for endowing the host lymphoid cells with immunologic com- petence. A lymphostimulatory effect of thymus epithelial reticular cells has been demonstrated in the work of Gregoire and Duchateau,6 who found that inoculation of these cells, or extracts prepared from them, produced hyperplas- tic alterations of the draining lymph nodes which were in their opinion significantly greater than those produced by administration of lymphatic tissue. In the studies reported herein, a single neonatal AKR thymus was sealed in a diffusion chamber which was then implanted intraperitoneally in an adult mouse and removed after 8 days. This resulted in a remnant which had lost the cortical cells and which was composed principally of epithelial reticular cells. This remnant was removed from the chamber and placed subcutaneously into 4 to 6 day old neonatally thymectomized C3HeB mice. Observations were made of the histology of the thymic grafts, and the

The effects of allografts of thymic epithelial reticular cells on the lymphoid tissues of neonatally thymectomized mice