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Compound 21 Prevents Salt Induced Myocardial Hypertrophy
Author(s) -
Dopona Ellen Priscila Brito,
Favoni Veronica,
Oliveira Ivone Braga,
Heimann Joel Claudio
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1216.19
Subject(s) - muscle hypertrophy , left ventricular hypertrophy , medicine , myocardial fibrosis , blood pressure , body weight , cardiac hypertrophy , weaning , cardiology , fibrosis , endocrinology
Objective To evaluate the role of Compound 21 (C21) in a model of salt overload on left (LV) and right (RV) ventricular hypertrophy and fibrosis. Methods Male Wistar rats were fed normal‐ (NS ‐ NaCl = 1,27%, n=8) or high‐ (HS ‐ NaCl = 8%; n=8) salt diet from weaning up to 18 weeks of age. From the 7th week of age, one HS subgroup received Compound 21 (1mg/kg per day by gavage, n=8). Body weight (BW), tail‐cuff blood pressure (BP), cardiac mass to tibia length ratio (CM/TL), cardiomyocyte transverse diameter (TD), percentage of cardiac fibrosis (FI) were measured. Results At 7th week of age, BW was higher in HS+C21 and NS than in HS. BW in HS+C21 did not differ from NS from the 7 th week to the 18 th week of age. BP in HS+C21 was higher than in NS and lower than in HS from the 7 th week to the 18 th week of age. Conclusion In Wistars rats, compound 21 prevents left and right ventricular hypertrophy and left ventricular fibrosis. Support or Funding Information This study was supported by FAPESP (2013/08418‐4) Results: (mean ± standard error of the mean ‐ p<0.05):Variable Weeks NS HS HS+C21Body Weigh (g) 3 65±1.5 65±2.4 64±3.5 18 560±19.4 493±16.4 * 566±15.5 BP(mmHg) 6 112±3.0 114±4.2 111±3.4 18 116±2.5 144±1.2 * 135±1.8 * #HEARTTotal 0.44±0.04 0.47±0.04 0.45±0.06 CM/TL (g/m) 18 RV 0.07±0.007 0.07±0.01 0.07±0.01LV 0.26±0.02 0.29±0.02 0.29±0.04 TD(μm) 18 RV 9.82±0.21 13.80±0.29 * 9.79±0.21LV 10.17±0.2 15.60±0.9 * 10.41±0.09 FI (% área) 18 RV 0.87±0.23 0.92±0.13 0.60±0.05LV 0.25±0.05 0.82±0.08 * 0.33±0.03 #* p<0.05 vs. NS; # p<0.05 vs. HS