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Molecular Indicators of Inflammation along Pathological Time‐line of Post‐traumatic Stress Disorder
Author(s) -
Muhie Seid,
Gautam Aarti,
Chakraborty Nabarun,
Hammamieh Rasha,
Meyerhoff James,
Jett Marti
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.888.13
Subject(s) - inflammation , pathological , chronic pain , medicine , traumatic stress , epigenetics , clinical psychology , bioinformatics , psychology , psychiatry , gene , biology , genetics
Post‐traumatic stress disorder (PTSD) in humans and PTSD‐like disorders in animal models tend to comorbid with inflammation, cardiovascular and metabolic disorders. Inflammation is implicated as the cause of chronic pain in PTSD patients. We assessed changes in the expression of genes known to mediate inflammation. We meta‐analyzed our in‐house generated data acquired from blood of PTSD patients, blood and brain parts of mouse models of PTSD, and similar data sets downloaded from public repositories. We did time‐line stratifications of the metadata to identify molecular indicators of chronological severity of inflammation accompanying pathologic progression of PTSD. Expression levels of genes mediating inflammation significantly increased at longer time points; in mice 6 weeks post social‐stress sessions, in rats after weeks of predator stress, in non‐human primates in accordance with chronic stressors of social hierarchies, and in humans, in correlation with chronic nature of PTSD symptoms. Regulators of inflammatory molecules (transcription factors, epigenetic regulators and microRNAs) also indicated increased severity of inflammation with prolonged PTSD symptoms (longer trauma memories). Our findings suggest that intervention of chronic PTSD should include ways of mitigating inflammation to alleviate chronic pain of PTSD patients. We thank the grant support of USAMRMC NO: 09284002. Research was conducted in compliance with all Federal requirements.