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Circulating Lymphocyte T cell levels following radical nonsmall cell tumor surgery
Author(s) -
TULP ORIEN LEE,
Einstein George P,
Kowalski Janusz,
Dancewicz Maciej
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.793.10
Subject(s) - cell , medicine , t cell , il 2 receptor , lymphocyte , t lymphocyte , oncology , pathology , immunology , cancer research , biology , immune system , genetics
T lymphocytes play an important role in mechanisms of immunological tolerance, where they contribute to tumor suppression activities. To determine the effects of surgical intervention on T cell status, a group of 21 patients with small cell lung cancer [NDRP], 13 of whom had confirmed lesions and 8 without who served as controls. The size and mass of all tumors were confirmed by MRI and PET scan imaging with Glu18 isotope enrichment. Measures of CD4/CD25 T cells before and after therapy resulted in a return toward normal of circulating T cell concentrations, consistent with a normalization of the expression and function of T lymphocytes after tumor reduction. These results suggest that the monitoring of circulating T cell populations may serve as viable indicators of treatment effectiveness for NDRP treatment. Institutional Support.