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FERTILITY ACTIVITY OF AQUEOUS LEAF EXTRACT OF TAPINANTHUS BANGWENSIS ON OVULATION IN FEMALE‐SPRAGUE DAWLEY RATS
Author(s) -
Onadeko Damilola,
Nwoke Stella C,
Magbagdeola Abiola O,
Ebuehi Albert O.,
Imaga Ngozi O,
Ajayi Godwin O.,
Gbotolorun Stella C
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1033.9
Subject(s) - ovulation , fertility , medicine , infertility , body weight , distilled water , zoology , physiology , pregnancy , endocrinology , gynecology , biology , chemistry , population , hormone , environmental health , chromatography , genetics
The fertility activity of Tapinanthus bangwensis in female rats were investigated in the present study. Twenty four cyclic female rats were administered orally at 1g/kg body weight between 140 and 200g. This was confirmed by checking their vaginal smear for four consecutive cycles. The animals were divided into eight groups of three rats each, group 1 animals served as the control and received equivalent volume of distilled water. Group 2 animals received clomiphene citrate( a fertility enhancing drug), group 3 received duofem(a contraceptive drug), Group 4,5 and 6 received the aqueous leaf extract at 100mg/kg, 200mg/kg and 300mg/kg respectively. group 7 received Vit E and group 8 received Folic acid. They were all administered orally at 9:00am on proestrus to determine it's effect on ovulation. Results revealed a significant difference at P<0.05 between the groups that received the extract at 100mg/kg, 200mg/kg and 300mg/kg. when compared to the control groups. The extract group gave higher mean values of 13.1 as compared to the control of mean value 7.3. Our result gives added scientific support to the use of Tapinanthus bangwensis in the treatment of infertility related problems in women.