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Effect of calcitonin gene‐related peptide (CGRP) on avian appetite‐related processes
Author(s) -
Calchary Wendy Alyssa,
Cline Mark A
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1166.11
Subject(s) - calcitonin gene related peptide , endocrinology , medicine , hypothalamus , appetite , arcuate nucleus , chemistry , calcitonin , nucleus , water intake , neuropeptide , biology , receptor , microbiology and biotechnology
Calcitonin gene‐related peptide (CGRP), consisting of 37 residues, is found in the gastrointestinal tract and causes reduced feed intake in mammals. Its effects in the avian class are unreported. We found that intraceberoventricular (ICV) injection of CGRP caused a linear decrease in feed and water intake in Cobb‐500 chicks. We determined that the effect on water intake was secondary to feed since feed‐restricted chicks did not have reduced water intake. Next, we found that an intaperitonal (IP) injection of CGRP reduced feed intake, but did not affect water intake. In order to determine if the hypothalamus was associated with these affects we examined c‐Fos immnoreactivity in several key appetite‐related nuclei. Both ICV and IP CGRP caused activation of the nucleus dorsomedialis hypothalami and the nucleus ifundibuli hypothalamis, the homolog of the mammalian arcuate nucleus. The results demonstrated that CGRP causes anorexigenic effect in chicks and the hypothalamus is involved.