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Identification of a novel SLC transporter
Author(s) -
Takahashi Shinichiro,
Hazama Akihiro,
Murakawa Masahiro
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1188-c
Subject(s) - subfamily , transporter , amino acid transporter , gene , biology , amino acid , solute carrier family , genetics , identification (biology) , peptide sequence , biochemistry , botany
A number of transporters which translocate various compounds were identified and functionally characterized over the last 20 years. We cloned a novel SLC transporter gene which is located on chromosome 12q13.13 and encodes a 450 amino acid protein. Although the closest subfamily to this transporter is glucose transporter family, the identity of the amino acid sequence is less than 20%. However, 95% of amino acids in mouse ortholog are identical. This novel transporter may belong to a novel SLC transporter subfamily and play an important role.