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Administration Spores of Ganoderma lucidum show elevated level of both TH1 and TH2 Cytokines in BALB/C mice
Author(s) -
Huang HuiYu,
Wu MingFang,
Chien ShihYung,
Chu HuiChun,
Wang YuChun
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1100-c
Ganoderma lucidum has been widely used in traditional Chinese medicines for preventing and treating various diseases. The spores of Ganoderma lucidum have higher bioactivities than those of the fruiting bodies of Ganoderma lucidum. This study examined the cytokine profiles after administration spores of Ganoderma lucidum in BALB/C mice for 8 weeks. The mice divided into control group and experiment group (administration 1750 and 3500 mg spores of Ganoderma lucidum/Kg BW). Compared the control group and experiment group, CD4+and NK cells number had a significant increase in experiment group. Our data revealed that both IFN‐£^and TNF‐£\ were expressed at high level in experiment group, which are know marker of activated T helper 1 lymphocytes. Furthermore, IL‐4, IL‐10, two key cytokines of the TH2 pathway, were expressed at higher levels in experiment group. These observations support the potential implication of the spores of Ganoderma lucidum could be a mediator of host immune defense and immune response modulator in both TH1 and TH2 pathways.