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Pathway analysis of genes related to bipolar disorder using gene ontology
Author(s) -
Meng Jingwei,
Barrett Thomas B.
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a62-b
Subject(s) - kegg , gene , bipolar disorder , genetics , biology , gene ontology , genetic linkage , biological pathway , computational biology , population , linkage (software) , genome , medicine , neuroscience , gene expression , cognition , environmental health
Bipolar Disorder (BPD) is one of the two major types of psychosis affecting more 1% of total population. Genetic linkage analysis suggests strong evidences that genetic background plays an important role in BPD. In this study, we explored the possible signaling pathways that involve genes that have been identified to be related to BPD in previous studies. Those genes were clustered primarily by their Gene Ontology (GO) and further reconstructed into signaling pathways based on Kyoto Encyclopedia of Genes and Genomes (KEGG) PATHWAY information. Our results indicated that BPD is a multiple genetic traits disease, while three major pathways involving calcium and cyclic AMP constitute 63% of BPD families we examined.