Open AccessInteraction among inflammasome, autophagy and non-coding RNAs: new horizons for drug
Author(s) -
Qinqin Pu,
Ping Lin,
Zhihan Wang,
Pan Gao,
Shugang Qin,
Luqing Cui,
Min Wu
Publication year - 2019
Publication title -
precision clinical medicine
Language(s) - English
Resource type - Journals
eISSN - 2096-5303
pISSN - 2516-1571
DOI - 10.1093/pcmedi/pbz019
Subject(s) - autophagy , inflammasome , crosstalk , biology , neurodegeneration , immune system , disease , signal transduction , computational biology , mechanism (biology) , pyroptosis , microbiology and biotechnology , neuroscience , bioinformatics , immunology , genetics , medicine , apoptosis , inflammation , philosophy , physics , epistemology , pathology , optics
Autophagy and inflammasomes are shown to interact in various situations including infectious disease, cancer, diabetes and neurodegeneration. Since multiple layers of molecular regulators contribute to the interplay between autophagy and inflammasome activation, the detail of such interplay remains largely unknown. Non-coding RNAs (ncRNAs), which have been implicated in regulating an expanding list of cellular processes including immune defense against pathogens and inflammatory response in cancer and metabolic diseases, may join in the crosstalk between inflammasomes and autophagy in physiological or disease conditions. In this review, we summarize the latest research on the interlink among ncRNAs, inflammasomes and autophagy and discuss the emerging role of these three in multiple signaling transduction pathways involved in clinical conditions. By analyzing these intriguing interconnections, we hope to unveil the mechanism inter-regulating these multiple processes and ultimately discover potential drug targets for some refractory diseases.