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Woodchucks {Marmota monax) naturally infected with a virus closely related to the human hepatitis B virus (HBV) serve as a model for liver disease and hepatocellular carcinoma in humans (1). Analysis of cellular sites for viral integration has identified myc family genes in about 30% of woodchuck liver tumors, and revealed the presence of two distinct, apparently functional Nmyc genes in the woodchuck genome (2; Fourel et al., submitted). N-myc 1 is homologous to other mammalian N-myc genes (3-5), similarly organized into three exons and two introns, whereas N-myc2 has the hallmarks of retroposons (Fourel et al., submitted). Here we report the nucleotide sequence and deduced amino acid sequence of the germline woodchuck N-myc 1 gene, isolated from a liver tumor genomic library made in XEMBL 3. Regions homologous to the three exons of the murine N-myc gene were subcloned and sequenced, showing that woodchuck, murine and human N-myc sequences are highly conserved (homology >85%). The predicted N-myc 1 encoded proteins (460 and 452 aa), initiated by two in phase AUG codons, harbor 90% homology with human and 86% homology with murine N-myc genes products.

Nucleotide sequence of the woodchuckN-mycgene (WN-myc1)