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The screening of a rat liver cDNA library with a hamster probe ACKNOWLEDGEMENTS that encompasses the nucleotides coding for the hamster enzyme . . . c . n T n w *~< J W C c A, , , • ,A A TAXI A A . U . 1 We are grateful to Drs. J.D.McGarry and V.Esser for providing (1), yielded a cDNA encoding the rat cytosolic ° yu 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase. t h e r a t h v e r c L W A l l b r a r y The cDNA spans 3275 bp and the only open reading frame codes REFERENCE for a protein of 520 amino acids, that is 97% homologous to the hamster cytosolic HMG-CoA synthase. '• Gil.G Goldstein.J.L S]aughter,C.A. and Brown.M.S. (1986) J. Bid J Chem. 261, 3710-3716.

Nucleotide sequence of a rat liver cDNA encoding the Cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase