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Below is the full-length DNA sequence (3123 bp) of'LTR.v-src.LTR provirus H-19.It was generated in the hamster genome by src mRNA reverse transcription and integration (1,2,3). Dupl ications of the chromosomal hexanucleotide sei, quence GCGGGG (indicated in underlined lower—case letters in the nucleotide sequence) flanking the two 2-base-pair-deleted LTRs is characteristic for regular RSV integration.Therefore the LTR.v-src.LTR structure, originating from src mRNA instead of genomic RNA of the Prague strain C of Rous sarcoma virus (PR-RSV-C) which was rescued froa rat XC cells (provirus II),had produced H-19 hamster cell transformation (4,5).

Complete nucleotide sequence of LTR, v-src, LTR provirus H-19