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SOURCE/DESCRIPTION: A 7.5 kb Bglll fragment from the cosmid RMR6 was subcloned into the BamHI site of pUC18. L POLYMORPHISM: TaqI identifies a 2 allele polymorphism with a r band at 2.5 kb (Tl) or 2.3 kb (T2) with a constant band at 1.5 h kb. CHROMOSOMAL LOCALIZATION: This probe has been assigned to chromosome 20 by linkage analysis (1) with a locus (D2OS1) known to span this chromosome (2). • • MENDELIAN INHERITANCE: Co-dominant segregation has been observed in 22 three generation families. L PROBE AVAILABILITY: Freely available (contact Y.N.) or will be available from ATCC. OTHER COMMENTS: RFLPs were observed after competitive hybridization with total human DNA.

Isolation and mapping of a polymorphic DNA sequence (pRMR6) on chromosome 20 (D20S20)