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SOURCE/DESCRIPTION: phins311 (vector-pBR322) contains an 8.6 kbp EcoRI fragment from the insulin (INS)/IGF2 genomic clone lambda hINS-3 (Bell et al 1985). This fragment contains an exon encoding part of the 5' untranslated region of IGF-II mRNA as well as adjacent intron sequences. POLYMORPHISM: BamHI digestion reveals invariant fragments of 17.0, 2.1, 1.8 and 1.0 kbp and polymorphic fragments of 2.2 kbp (allele 1) and 1.2 kbp (allele 2). The IGF2 gene is immediately adjacent to the 3 1 end of the insulin gene. MENDELIAN INHERITANCE: Co-dominant segregation observed in three families. OTHER COMMENTS: This probe may be useful in those instances when it is not possible to distinguish each parental gene using an insulin hypervariable region probe.

BamHI RFLP at the insulin-like growth factor II (IGF2) locus on chromosome 11