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Iron is an essential element for  Vibrio cholerae  to survive, and Feo, the major bacterial system for ferrous iron transport, is important for growth of this pathogen in low-oxygen environments. To gain insight into its biochemical mechanism, we evaluated the effects of widely used ATPase inhibitors on the ATP hydrolysis activity of the N-terminal domain of  V. cholerae  FeoB. Our results showed that sodium orthovanadate and sodium azide effectively inhibit the catalytic activity of the N-terminal domain of  V. cholerae  FeoB. Further, sodium orthovanadate was the more effective inhibitor against  V. cholerae  ferrous iron transport  in vivo . These results contribute to a more comprehensive biochemical understanding of Feo function, and shed light on designing effective inhibitors against bacterial FeoB proteins.

Vanadate inhibits Feo-mediated iron transport in Vibrio cholerae