Open AccessWblA, a global regulator of antibiotic biosynthesis in Streptomyces
Author(s) -
HeeJu Nah,
Ji-Hee Park,
SiSun Choi,
Eung-Soo Kim
Publication year - 2021
Publication title -
journal of industrial microbiology and biotechnology/journal of industrial microbiology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.857
H-Index - 112
eISSN - 1476-5535
pISSN - 1367-5435
DOI - 10.1093/jimb/kuab007
Subject(s) - streptomyces , actinobacteria , biosynthesis , regulator , biology , streptomycetaceae , bacteria , antibiotics , synthetic biology , computational biology , actinomycetales , microbiology and biotechnology , biochemistry , genetics , gene , 16s ribosomal rna
Streptomyces species are soil-dwelling bacteria that produce vast numbers of pharmaceutically valuable secondary metabolites (SMs), such as antibiotics, immunosuppressants, antiviral, and anticancer drugs. On the other hand, the biosynthesis of most SMs remains very low due to tightly controlled regulatory networks. Both global and pathway-specific regulators are involved in the regulation of a specific SM biosynthesis in various Streptomyces species. Over the past few decades, many of these regulators have been identified and new ones are still being discovered. Among them, a global regulator of SM biosynthesis named WblA was identified in several Streptomyces species. The identification and understanding of the WblAs have greatly contributed to increasing the productivity of several Streptomyces SMs. This review summarizes the characteristics and applications on WblAs reported to date, which were found in various Streptomyces species and other actinobacteria.