Open AccessA time-resolved experimental–mathematical model for predicting the response of glioma cells to single-dose radiation therapy
Author(s) -
Junyan Liu,
David A. Hormuth,
Tessa Davis,
Jianchen Yang,
Matthew T. McKenna,
Angela M. Jarrett,
Heiko Enderling,
Amy Brock,
Thomas E. Yankeelov
Publication year - 2021
Publication title -
integrative biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 70
eISSN - 1757-9708
pISSN - 1757-9694
DOI - 10.1093/intbio/zyab010
Subject(s) - concordance correlation coefficient , glioma , pearson product moment correlation coefficient , radiation therapy , biological system , correlation coefficient , standard deviation , correlation , radiation , coefficient of variation , nuclear medicine , mathematics , statistics , biology , medicine , physics , surgery , optics , geometry , cancer research
To develop and validate a mechanism-based, mathematical model that characterizes 9L and C6 glioma cells' temporal response to single-dose radiation therapy in vitro by explicitly incorporating time-dependent biological interactions with radiation.