Open AccessComparative Analysis of the Antiviral Effects Mediated by Type I and III Interferons in Hepatitis B Virus–Infected Hepatocytes
Author(s) -
JanHendrik Bockmann,
Daniela Stadler,
Yuchen Xia,
Chunkyu Ko,
Jochen M. Wettengel,
Julian Schulze zur Wiesch,
Maura Dandri,
Ulrike Protzer
Publication year - 2019
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiz143
Subject(s) - cccdna , hepatitis b virus , biology , virology , interferon , hepatitis b virus pre beta , cytosine , virus , microbiology and biotechnology , apobec , dna , hepatitis b virus dna polymerase , biochemistry , gene , hbsag , genome
Type III interferons (IFNs) (λ1-3) activate similar signaling cascades as type I IFNs (α and β) via different receptors. Since IFN-α and lymphotoxin-β activate cytosine deamination and subsequent purging of nuclear hepatitis B virus (HBV) DNA, we investigated whether IFN-β and -λ may also induce these antiviral effects in differentiated HBV-infected hepatocytes.
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