Open AccessFostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic
Author(s) -
Jeffrey R. Strich,
Marcos J. Ramos-Benítez,
Davide Randazzo,
Sydney Stein,
Ashley L. Babyak,
Richard T. Davey,
Anthony F. Suffredini,
Richard Childs,
Daniel S. Chertow
Publication year - 2020
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiaa789
Subject(s) - covid-19 , extracellular , neutrophil extracellular traps , medicine , virology , convalescent plasma , immunology , chemistry , pharmacology , inflammation , biochemistry , outbreak , infectious disease (medical specialty) , disease
Neutrophil extracellular traps (NETs) contribute to immunothrombosis and have been associated with mortality in coronavirus disease 2019 (COVID-19). We stimulated donor neutrophils with plasma from patients with COVID-19 and demonstrated that R406 can abrogate the release of NETs. These data provide evidence for how fostamatinib may mitigate neutrophil-associated mechanisms contributing to COVID-19 immunopathogenesis.
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