Open AccessPretransplant Cytomegalovirus-Specific Cellular Immunity and Risk of Viral Reactivation Following Lung Transplantation: A Prospective Cohort Study
Author(s) -
Mohammed Altaf,
Katie E. Lineburg,
Pauline Crooks,
Sweera Rehan,
Katherine Matthews,
Michelle A. Neller,
George Ambalathingal,
Debottam Sinha,
Michelle Grant,
Peter Hopkins,
Daniel C. Chambers,
Rajiv Khanna,
Corey Smith
Publication year - 2020
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiaa750
Subject(s) - medicine , prospective cohort study , cytomegalovirus , immunology , immunity , lung transplantation , transplantation , betaherpesvirinae , cellular immunity , lung , incidence (geometry) , immune system , viral disease , herpesviridae , virus , physics , optics
Cytomegalovirus (CMV) remains a significant burden in lung transplant recipients. Deficiencies in T-cell immunity posttransplant increase the risk of CMV-associated complications. However, it is not clear if underlying poor pretransplant immunity increases risk. To assess this, we recruited 39 prospective lung transplant patients and performed QuantiFERON-CMV on their peripheral blood. More than a third of prospective CMV-seropositive transplant recipients were CMV non-immune reactive (CMV-NIR) pretransplant. CMV-NIR status was associated with a significantly higher incidence of CMV reactivation posttransplant, demonstrating that dysfunctional CMV immunity in prospective lung transplant recipients is associated with an increased risk of viral reactivation posttransplant.
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