Open AccessLiCl Pretreatment Ameliorates Adolescent Methamphetamine Exposure-Induced Long-Term Alterations in Behavior and Hippocampal Ultrastructure in Adulthood in Mice
Author(s) -
Yan Peng,
Dan Xu,
Yuanyuan Ji,
Fangyuan Yin,
Jingjing Cui,
Rui Su,
Yunpeng Wang,
Yan Zhu,
Shuguang Wei,
Jianghua Lai
Publication year - 2019
Publication title -
international journal of neuropsychopharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 107
eISSN - 1469-5111
pISSN - 1461-1457
DOI - 10.1093/ijnp/pyz001
Subject(s) - methamphetamine , gsk 3 , hippocampus , hippocampal formation , prefrontal cortex , psychology , endocrinology , dendritic spine , postsynaptic density , gsk3b , neuroscience , medicine , chemistry , excitatory postsynaptic potential , kinase , biochemistry , cognition , inhibitory postsynaptic potential
Adolescent methamphetamine exposure causes a broad range of neurobiological deficits in adulthood. Glycogen synthase kinase-3β is involved in various cognitive and behavioral processes associated with methamphetamine exposure. This study aims to investigate the protective effects of the glycogen synthase kinase-3β inhibitor lithium chloride on adolescent methamphetamine exposure-induced long-term alterations in emotion, cognition, behavior, and molecule and hippocampal ultrastructure in adulthood.