Open AccessThe physical presence of gallstone modulatesex vivocholesterol crystallization pathways of human bile
Author(s) -
Piero Portincasa,
Karel J. van Erpecum,
Agostino Di Ciaula,
David Q.–H. Wang
Publication year - 2018
Publication title -
gastroenterology report
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 26
eISSN - 2052-0034
pISSN - 2304-1412
DOI - 10.1093/gastro/goy044
Subject(s) - cholesterol , gallstones , anhydrous , crystallization , cholecystectomy , gallbladder , medicine , chemistry , organic chemistry
Cholesterol crystallization is an essential step toward gallstone formation. Although model bile studies showed that competition occurs between the gallstone surface and the surrounding aqueous phase for cholesterol molecules available for crystallization, this has not been investigated in human bile.