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Stress induces peroxisome biogenesis genes
Author(s) -
LopezHuertas Eduardo,
Charlton Wayne L,
Johnson Barbara,
Graham Ian A,
Baker Alison
Publication year - 2000
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1093/emboj/19.24.6770
Subject(s) - peroxisome , biology , biogenesis , luciferase , microbiology and biotechnology , reactive oxygen species , hydrogen peroxide , biochemistry , gene , transfection
Peroxisomes are the cellular location of many antioxidants and are themselves significant producers of reactive oxygen species. In this report we demonstrate the induction of peroxisome biogenesis genes in both plant and animal cells by the universal stress signal molecule hydrogen peroxide. Using PEX 1– LUC transgenic plants, rapid local and systemic induction of PEX 1–luciferase could be demonstrated in vivo in response to physiological levels of hydrogen peroxide. PEX 1–luciferase was also induced in response to wounding and to infection with an avirulent pathogen. We propose a model in which various stress situations that lead to the production of hydrogen peroxide can be ameliorated by elaboration of the peroxisome compartment to assist in restoration of the cellular redox balance.