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Identification of Bach2 as a B‐cell‐specific partner for small Maf proteins that negatively regulate the immunoglobulin heavy chain gene 3′ enhancer
Author(s) -
Muto Akihiko,
Hoshino Hideto,
Madisen Linda,
Yanai Nobuaki,
Obinata Masuo,
Karasuyama Hajime,
Hayashi Norio,
Nakauchi Hiromitsu,
Yamamoto Masayuki,
Groudine Mark,
Igarashi Kazuhiko
Publication year - 1998
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1093/emboj/17.19.5734
Subject(s) - library science , biology , computer science
Maf family transcription factors are important regulators in various differentiation systems. Putative Maf recognition elements (MAREs) are found in the 3′ enhancer region of the immunoglobulin heavy chain (IgH) gene. These elements are bound in B‐cell extracts by a heterodimeric protein complex containing both Bach2 and a small Maf protein. Analysis of normal hematopoietic cells revealed that Bach2 is specifically expressed in B cells. Bach2 is abundantly expressed in the early stages of B‐cell differentiation and turned off in terminally differentiated cells. Bach2 acts together with MafK as a negative effector of the IgH 3′ enhancer and binds to the co‐repressor SMRT (silencing mediator of retinoid and thyroid receptor). Hence the Bach2–small‐Maf heterodimer may represent the first example of a B‐cell lineage, and of a developmental stage‐restricted negative effector of the MARE in the IgH 3′ enhancer region.