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Background Patients with chronic diseases, particularly those requiring immunosuppression, are thought to be at increased risk of poor mental health during the COVID-19 pandemic. However, few studies have assessed the mental health of such patients during the current or past pandemics. We aimed to assess the incidence of depression, anxiety &amp; stress in a cohort of inflammatory bowel disease (IBD) patients early during the COVID-19 pandemic, &amp; explore for association with risk of severe COVID-19 based on British Society of Gastroenterology guidelines, &amp; other factors. Methods A survey including the Patient Health Questionnaire-9, General Anxiety Disorder-7, &amp; Perceived Stress Scale tools for depression, anxiety &amp; stress, respectively, was administered to a cohort of IBD patients from a tertiary centre in London, United Kingdom, in June 2020. Results 274 patients responded to the survey (57% response rate), including 54 low risk, 152 moderate risk, &amp; 68 high risk for severe COVID-19. Moderate-severe depression was observed in 61 (22.5%), moderate-severe anxiety in 49 (18%), while 39 (14%) had both diagnoses (Table). Mean (SD) stress score was 16.2 (7.4). There was no association between degree of severe COVID-19 risk &amp; psychological morbidity. Flare symptoms &amp; fatigue were associated with worse psychological morbidity across all measures, while accessibility of information regarding COVID-19 risk &amp; reducing that risk was protective for depression (OR 0.56 [0.33–0.94], p=0.03), anxiety (OR 0.62 [0.4–0.96], p=0.03), &amp; stress (standardized β-coefficient -0.15 [-0.28--0.03], p=0.02) (Figure). 79 (30%) respondents were interested in receiving psychological support during the pandemic, while 200 (76%) expressed interest beyond the pandemic. Conclusion Depression, anxiety &amp; stress among IBD patients during the pandemic are common, however their frequency is similar to pre-pandemic rates &amp; general population levels reported during the same period. Ensuring easy access to personalized risk information with targeted psychological support may mitigate psychological burden as patients reintegrate into society &amp; deal with future COVID-19 waves or variants.

P128 Depression, anxiety and stress among Inflammatory Bowel Disease patients during COVID-19: A UK cohort study