Open AccessMesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization
Author(s) -
Jinxuan Zhao,
Xueling Li,
Jiaxin Hu,
Fu Chen,
Shuaihua Qiao,
Xuan Sun,
Ling Gao,
Jun Xie,
Baojun Xu
Publication year - 2019
Publication title -
cardiovascular research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvz040
Subject(s) - mesenchymal stem cell , microvesicles , macrophage polarization , inflammation , tlr4 , macrophage , medicine , reperfusion injury , exosome , stromal cell , cancer research , in vivo , transplantation , microbiology and biotechnology , pharmacology , immunology , ischemia , in vitro , chemistry , biology , microrna , pathology , biochemistry , gene
Mesenchymal stromal cells (MSCs) gradually become attractive candidates for cardiac inflammation modulation, yet understanding of the mechanism remains elusive. Strikingly, recent studies indicated that exosomes secreted by MSCs might be a novel mechanism for the beneficial effect of MSCs transplantation after myocardial infarction. We therefore explored the role of MSC-derived exosomes (MSC-Exo) in the immunomodulation of macrophages after myocardial ischaemia/reperfusion (I/R) and its implications in cardiac injury repair.