Open AccessEffects of early high-dose erythropoietin on acute kidney injury following cardiac arrest: exploratory post hoc analyses from an open-label randomized trial
Author(s) -
Lucie Guillemet,
Matthieu Jamme,
Wulfran Bougouin,
Guillaume Géri,
Nicolas Deye,
Benoît Vivien,
Olivier Varenne,
Frédéric Pène,
JeanPaul Mira,
Florence Barat,
JeanMarc Tréluyer,
Olivier Hermine,
Pierre Carli,
Joël Coste,
Alain Cariou
Publication year - 2019
Publication title -
clinical kidney journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 40
eISSN - 2048-8513
pISSN - 2048-8505
DOI - 10.1093/ckj/sfz068
Subject(s) - medicine , acute kidney injury , erythropoietin , clinical endpoint , post hoc analysis , randomized controlled trial , epoetin alfa , intensive care unit , renal function , kidney disease , anesthesia
Acute kidney injury (AKI) is frequent in patients resuscitated from cardiac arrest (CA) and may worsen outcome. Experimental data suggest a renoprotective effect by treating these patients with a high dose of erythropoietin (Epo) analogues. We aimed to evaluate the efficacy of epoetin alpha treatment on renal outcome after CA.