Open AccessPerformance of real-time PCR in suspected haemodialysis catheter-related bloodstream infection: a proof-of-concept study
Author(s) -
Mathieu Acquier,
Arnaud Zabala,
V. De Précigout,
Yahsou Delmas,
Véronique Dubois,
Renaud de la Faille,
Sébastien Rubin,
Christian Combe,
Fatima M’Zali,
Hannah Kaminski
Publication year - 2022
Publication title -
clinical kidney journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 40
eISSN - 2048-8513
pISSN - 2048-8505
DOI - 10.1093/ckj/sfac242
Subject(s) - medicine , blood culture , staphylococcus aureus , antibiotics , staphylococcus , real time polymerase chain reaction , polymerase chain reaction , microbiology and biotechnology , gastroenterology , bacteria , biology , biochemistry , genetics , gene
Catheter-related bloodstream infections (CRBIs) remain a major cause of mortality in haemodialysis (HD) patients with central venous catheters (CVCs), especially because of the non-specific symptomatology and the delay in microbiological diagnosis with possible use of non-optimal empiric antibiotics. Moreover, empiric broad-spectrum antibiotics increase antibiotic resistance development. This study aims to evaluate the diagnostic performance of real-time polymerase chain reaction (rt-PCR) in suspected HD CRBIs compared with blood cultures.