Open AccessSearching and Finding the Hidden Treasure: A Retrospective Analysis of Rickettsial Disease Among Dutch International Travelers
Author(s) -
Sophia G. de Vries,
Louise E. van Eekeren,
Hans van der Linden,
Benjamin J. Visser,
Martin P. Grobusch,
Jiri F. P. Wagenaar,
Marga G. A. Goris,
Abraham Goorhuis
Publication year - 2020
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciaa091
Subject(s) - serology , medicine , eschar , scrub typhus , leptospirosis , spotted fever , orientia tsutsugamushi , retrospective cohort study , pediatrics , typhus , murine typhus , surgery , immunology , virology , rickettsia , antibody , virus
Rickettsial disease (RD) is a prevalent and underestimated cause of febrile illness worldwide, especially in the absence of an inoculation eschar. We attempted to quantify this underestimation at our clinic, by investigating past cases of febrile illness in travelers who had tested negative for leptospirosis, a disease that can initially present similarly to non-eschar RD, and which we routinely consider when other important causes of unspecified febrile illness have tested negative.