Open AccessA Distinct Population of L6 Neurons in Mouse V1 Mediate Cross-Callosal Communication
Author(s) -
Yajie Liang,
Jiang Lan Fan,
Wenzhi Sun,
Rongwen Lu,
Ming Chen,
Na Ji
Publication year - 2021
Publication title -
cerebral cortex
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.694
H-Index - 250
eISSN - 1460-2199
pISSN - 1047-3211
DOI - 10.1093/cercor/bhab084
Subject(s) - neuroscience , corpus callosum , population , sensory system , receptive field , visual cortex , biology , thalamus , stimulus (psychology) , cerebral cortex , excitatory postsynaptic potential , ocular dominance , psychology , inhibitory postsynaptic potential , medicine , environmental health , psychotherapist
Through the corpus callosum, interhemispheric communication is mediated by callosal projection (CP) neurons. Using retrograde labeling, we identified a population of layer 6 (L6) excitatory neurons as the main conveyer of transcallosal information in the monocular zone of the mouse primary visual cortex (V1). Distinct from L6 corticothalamic (CT) population, V1 L6 CP neurons contribute to an extensive reciprocal network across multiple sensory cortices over two hemispheres. Receiving both local and long-range cortical inputs, they encode orientation, direction, and receptive field information, while are also highly spontaneous active. The spontaneous activity of L6 CP neurons exhibits complex relationships with brain states and stimulus presentation, distinct from the spontaneous activity patterns of the CT population. The anatomical and functional properties of these L6 CP neurons enable them to broadcast visual and nonvisual information across two hemispheres, and thus may play a role in regulating and coordinating brain-wide activity events.