Open AccessMicroscale Physiological Events on the Human Cortical Surface
Author(s) -
Angelique C. Paulk,
Jimmy C. Yang,
Daniel R. Cleary,
Daniel J. Soper,
Milan Halgren,
Alexandra R. O’Donnell,
SangHeon Lee,
Mehran Ganji,
Yun Goo Ro,
Hongseok Oh,
Lorraine Hossain,
JiHwan Lee,
Youngbin Tchoe,
Nicholas Rogers,
Kıvılcım Kılıç,
Sang−Wan Ryu,
Seung Woo Lee,
John Hermiz,
Vikash Gilja,
István Ulbert,
Dániel Fabó,
Thomas Thesen,
Werner Doyle,
Orrin Devinsky,
Joseph R. Madsen,
Donald L. Schomer,
Emad N. Eskandar,
Jong Woo Lee,
Douglas Maus,
Anna Devor,
Shelley I. Fried,
Pamela S. Jones,
Brian V. Nahed,
Sharona BenHaim,
Sarah K Bick,
R. Mark Richardson,
Ahmed M. Raslan,
Dominic A. Siler,
Daniel P. Cahill,
Ziv Williams,
G. Rees Cosgrove,
Shadi A. Dayeh,
Sydney S. Cash
Publication year - 2021
Publication title -
cerebral cortex
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.694
H-Index - 250
eISSN - 1460-2199
pISSN - 1047-3211
DOI - 10.1093/cercor/bhab040
Subject(s) - neuroscience , multielectrode array , microscale chemistry , microelectrode , human brain , electrophysiology , neocortex , cortical neurons , electroencephalography , biology , psychology , chemistry , electrode , mathematics education
Despite ongoing advances in our understanding of local single-cellular and network-level activity of neuronal populations in the human brain, extraordinarily little is known about their "intermediate" microscale local circuit dynamics. Here, we utilized ultra-high-density microelectrode arrays and a rare opportunity to perform intracranial recordings across multiple cortical areas in human participants to discover three distinct classes of cortical activity that are not locked to ongoing natural brain rhythmic activity. The first included fast waveforms similar to extracellular single-unit activity. The other two types were discrete events with slower waveform dynamics and were found preferentially in upper cortical layers. These second and third types were also observed in rodents, nonhuman primates, and semi-chronic recordings from humans via laminar and Utah array microelectrodes. The rates of all three events were selectively modulated by auditory and electrical stimuli, pharmacological manipulation, and cold saline application and had small causal co-occurrences. These results suggest that the proper combination of high-resolution microelectrodes and analytic techniques can capture neuronal dynamics that lay between somatic action potentials and aggregate population activity. Understanding intermediate microscale dynamics in relation to single-cell and network dynamics may reveal important details about activity in the full cortical circuit.