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Dopamine receptors play an important role in motivational, emotional, and motor responses. In addition, growing evidence suggests a key role of hippocampal dopamine receptors in learning and memory. It is well known that associative learning and synaptic plasticity of CA3-CA1 requires the dopamine D 1  receptor (D 1 R). However, the specific role of the dopamine D 2  receptor (D 2 R) on memory-related neuroplasticity processes is still undefined. Here, by using two models of D 2 R loss, D 2 R knockout mice  (Drd2   −/−   )  and mice with intrahippocampal injections of  Drd2- small interfering RNA ( Drd2 -siRNA), we aimed to investigate how D 2 R is involved in learning and memory as well as in long-term potentiation of the hippocampus. Our studies revealed that the genetic inactivation of D 2 R impaired the spatial memory, associative learning, and the classical conditioning of eyelid responses. Similarly, deletion of D 2 R reduced the activity-dependent synaptic plasticity in the hippocampal CA1-CA3 synapse. Our results demonstrate the first direct evidence that D 2 R is essential in behaving mice for trace eye blink conditioning and associated changes in hippocampal synaptic strength. Taken together, these results indicate a key role of D 2 R in regulating hippocampal plasticity changes and, in consequence, acquisition and consolidation of spatial and associative forms of memory.

Dopamine D 2 R is Required for Hippocampal-dependent Memory and Plasticity at the CA3-CA1 Synapse