Open AccessOxidative stress-induced downregulation of glycogen synthase kinase 3 beta in fetal membranes promotes cellular senescence†
Author(s) -
Narmada Lavu,
Lauren Richardson,
Enkhtuya Radnaa,
Talar Kechichian,
Rheanna UrrabazGarza,
Samantha ShellerMiller,
Elizabeth A. Bonney,
Ramkumar Me
Publication year - 2019
Publication title -
biology of reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.366
H-Index - 180
eISSN - 1529-7268
pISSN - 0006-3363
DOI - 10.1093/biolre/ioz119
Subject(s) - gsk 3 , biology , gsk3b , senescence , microbiology and biotechnology , kinase , glycogen synthase , oxidative stress , downregulation and upregulation , phosphorylation , biochemistry , gene
Oxidative stress (OS)-induced stress signaler p38 mitogen-activated protein kinase (p38MAPK) activation and fetal membrane senescence are associated with parturition. This study determined changes in glycogen synthase kinase 3 beta (GSK3β) and its regulation by p38MAPK in effecting senescence to further delineate the molecular mechanism involved in senescence.