Open AccessAssociation of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals
Author(s) -
Pooja R. Mandaviya,
Roby Joehanes,
Jennifer A. Brody,
Juan CastilloFernandez,
Koen F. Dekkers,
Anh N.,
Mariaelisa Graff,
Ismo Hänninen,
Toshiko Tanaka,
Ester AL de Jonge,
Jessica C. Kiefte–de Jong,
Devin Absher,
Stella Aslibekyan,
Yolanda B. de Rijke,
Myriam Fornage,
Dena Hernández,
Mikko Hurme,
M. Arfan Ikram,
Paul F. Jacques,
Anne E. Justice,
Douglas P. Kiel,
Rozenn N. Lemaître,
Michael Mendelson,
Vera Mikkilä,
Ann Zenobia Moore,
Tess Pallister,
Olli Raitakari,
Casper G. Schalkwijk,
Jin Sha,
Eline P. E. Slagboom,
Caren E. Smith,
Coen D.A. Stehouwer,
Pei-Chien Tsai,
André G. Uitterlinden,
Carla Kallen,
Diana van Heemst,
Donna K. Arnett,
Stefania Bandinelli,
Jordana T. Bell,
Bastiaan T. Heijmans,
Terho Lehtimäki,
Daniel Levy,
Kari E. North,
a Sotoodehnia,
Marleen M. J. van Greevenbroek,
Joyce B. J. van Meurs,
Sandra G. Heil
Publication year - 2019
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.1093/ajcn/nqz031
Subject(s) - dna methylation , epigenome , differentially methylated regions , biology , epigenetics , methylation , genetics , gene , medicine , physiology , gene expression
Folate and vitamin B-12 are essential micronutrients involved in the donation of methyl groups in cellular metabolism. However, associations between intake of these nutrients and genome-wide DNA methylation levels have not been studied comprehensively in humans.
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