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Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique used to treat neuropsychiatric disorders. Despite its efficacy, its neuro-mechanisms remain unclear. Brain entropy (BEN), a measure of the irregularity and complexity of brain activity, has been shown to reflect the effects of high-frequency rTMS (HF-rTMS). However, it remains unknown whether BEN is sensitive to low-frequency rTMS (LF-rTMS), as well as to target-specific effects.

Altered resting-state brain entropy by repetitive transcranial magnetic stimulation across the human cortex