Open AccessChlamydomonas reinhardtiiformin FOR1 and profilin PRF1 are optimized for acute rapid actin filament assembly
Author(s) -
Jenna R Christensen,
Evan W. Craig,
Michael J. Glista,
David M. Mueller,
Yujie Li,
Jennifer A. Sees,
Shengping Huang,
Cristian Suarez,
Laurens Mets,
David R. Kovar,
Prachee Avasthi
Publication year - 2019
Publication title -
molecular biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.463
H-Index - 225
eISSN - 1939-4586
pISSN - 1059-1524
DOI - 10.1091/mbc.e19-08-0463
Subject(s) - formins , profilin , biology , microbiology and biotechnology , chlamydomonas , mdia1 , actin remodeling , actin , chlamydomonas reinhardtii , actin remodeling of neurons , actin cytoskeleton , biochemistry , mutant , cytoskeleton , gene , cell
An algal profilin PRF1 inhibits actin filament nucleation and elongation at low concentrations that can be overcome by the formin FOR1 for rapid actin assembly. FOR1 is required for assembly of a mating structure in gametic algal cells. Together, FOR1 and PRF1 cooperate to selectively assemble F-actin at the right time and place.