Open AccessGlucocorticoids and myosin5b loss of function induce heightened PKA signaling in addition to membrane traffic defects
Author(s) -
Radia Forteza,
Md. Kaimul Ahsan,
Fernando Cartón-García,
Diego Arango,
Nadia Ameen,
Pedro J. Salas
Publication year - 2019
Publication title -
molecular biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.463
H-Index - 225
eISSN - 1939-4586
pISSN - 1059-1524
DOI - 10.1091/mbc.e18-07-0415
Subject(s) - biology , microbiology and biotechnology , function (biology) , signal transduction , loss function , membrane , biochemistry , phenotype , gene
Loss-of-function mutations in myosin Vb lead to defects in apical membrane traffic in enterocytes in microvillus inclusion disease. This work shows that decreased numbers of apical CFTR molecules are more active for Cl − secretion resulting in profuse diarrhea because of PKA activation in the presence of physiological glucocorticoid concentrations.