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Female white rats were exposed during up to 6 months 5 times a week, 4 hr per day in a “nose only” inhalation device to an aerosol containing predominantly submicron (nanoscale included) particles of amorphous silica in the concentration 2.6±0.6 or 10.6±2.1 mg/m 3 . In an auxiliary experiment with a single-shot intratracheal instillation of these particles, it was shown that they induced a pulmonary cell response comparable with that to highly cytotoxic and fibrogenic standard quartz powder DQ 12 . However, in the long-term inhalation test, the studied aerosol proved to be of very low systemic toxicity and fibrogenicity. This paradox may be explained by low SiO 2  retention in lungs and other organs due to a relatively high  in vivo  solubility of these nanoparticles. Nevertheless, their genotoxic action and transnasal penetration into the brain should make one give a cautious overall assessment of this aerosol as an occupational or environmental hazard.

Organism’s responses to a long-term inhalation of silica-containing submicron particles of an industrial aerosol