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Cucumber suri ( Cucumis melo  L.) is one of natural materials which has many bioactivities, such as antioxidant, antifungal, antibacterial, anti-cholesterol, antidiabetic, and several other activities. Eventough, Cucumber suri ( Cucumis melo  L.) has a fairly low flavonoid content. In addition, bioactive compounds in cucumber suri seeds tend to be difficult to dissolve in water, unstable to pH, and even have a low bioavailability. Nanoparticles can be used to increase the activity of natural materials by using chitosan and sodium tripolyphosphate as crosslinking agents. This study aims to determine the characteristics of nano chitosan-cucumber suri seeds ( Cucumis melo  L.). First, Cucumber Suri seeds weas previously extracted using maceration method and identified theirs bioactive compounds. And then, Cucumber Suri seed extract was encapsulated with Chitosan: STPP (5: 1). Characterization test was carried out using UV-Vis Spectrophotometry, Infrared Spectrophotometry, and Particle Size Analyzer (PSA). The encapsulation process of Cucumber Suri seed extract produces a clear, homogeneous and stable supernatant. The values of characterization with UV-Vis Spectrophotometry in 0 to 60 minutes was &gt;90%, that indicated nanosized particleswas succefully formed. The IR characterization values indicate a shift in the nano chitosan-cucumber suri seeds wavelength compare with chitosan. The shift of –OH stretching vibration at wavelength 3403 cm −1  and stretching vibration of C=O in 1642 cm −1  showed there was an interaction between chitosan and Cucumber Suri seed extract. Analysis using Particle Size Analyzer (PSA) showed that chitosan-cucumber suri seeds had a normal polydispersion index (PI) of 0.677 and average particle diameter size was 360 nm.

Characterization of Nano Chitosan-Cucumber Suri (Cucumis melo L.) Seeds with Sodium Tripolyphosphate as Crosslinker