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The ecological niches occupied by  E. coli  are not limited to the environment, this bacterium is part of the symbiotic and conditionally pathogenic microflora of humans and animals.  E. coli  strains are highly resistant to various antibiotics, which poses a threat to ecological stability in the biodiversity of species. Once in unfavorable conditions,  E. coli  can acquire pathogenic properties and cause dangerous diseases, one of which is enterotoxigenic escherichiosis. The reservoir of pathogenic  E. coli  in the environment can be both farm animals and animal products. Timely and effective immunization of animals against escherichiosis is relevant for veterinary medicine and medicine, and the search for new biological products for treatment and prevention is one of the important practical tasks. The preventive effectiveness of the use of anatoxin vaccine samples in combination with an adjuvant complex in enterotoxigenic escherichiosis of animals was studied as a new solution to stabilize the ecological situation of anthropospheric genesis in the form of reducing the spread of antibiotic-resistant strains of  E. coli  in the environment. As a result of the conducted studies, it was established that after the use of an anatoxin vaccine with an adjuvant complex, high preventive efficacy is provided for enterotoxigenic escherichiosis.

Prevention of enterotoxigenic escherichiosis as a way to stabilize the ecological situation of anthropogenic pollution by antibiotic-resistant strains