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Endosymbiont fungi from marine sponges are a rich source of medicinally active compounds. Indonesia has a huge number of marine sponges. This research was conducted to determine the antibacterial potential of endosymbiont fungi isolated from marine sponges collected from Kotok Kecil Island, Seribu Islands. The screening was conducted with two methods, the modified GIBEX and disc diffusion. Species of marine sponges were isolated, namely  Petrosia  sp.,  Stylissa carteri, Cinachyrella australiensis, Callyspongia  sp.,  Petrosia nigrians , and  Stylissa massa , and obtained 9 isolates of endosymbiont fungi. The GIBEX test against  Escherichia coli  and  Streptococcus mutans  showed that ethyl acetate extract had strongest antibacterial activity. Disc diffusion test of ethyl acetate extract, five isolates had antibacterial activity against  S. mutans  and four against  E. coli . The isolate that showed the strongest antibacterial activity was from  Petrosia  sp. Which has an inhibition zone of 8.4 mm against  E. coli  and 7.45 mm against  S. mutans . The main active compounds from the isolate of  Petrosia  sp. are butylhydroxytoluene and phthalic acid di-(2-propylpentyl) esters. Based on this study, we concluded that the endosymbiont fungi of marine sponges are potential to be developed for further development as source of antibacterial agents.

Antibacterial activity of endosymbiotic fungi isolated from marine sponges collected from Kotok Kecil Island, Seribu Islands, Jakarta