English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Citrus maxima  pectin has a function to serve as a superdisintegrant due to its hydrophilicity, its high methoxyl content, and its great affinity for water. It allows the acceleration of the disintegration time of the orodispersible film. This study aims to determine the superdisintegration effect of  Citrus maxima  pectin on orodispersible film characteristics. Initially,  Citrus maxima  pectins were extracted and evaluated for organoleptic properties, qualitative tests, loss on drying, ash content, equivalent weight, and methoxyl content. Orodispersible film of dextromethorphan hydrobromide was formulated in 5 formulas with varying concentrations of 2%, 4%, 6%, 8%, and 10%. The films were evaluated for their organoleptic properties, uniformity of weight, thickness, tensile strength, elongation, pH, disintegration time, determination of content, and drug uniformity. The pectin from  Citrus maxima  has been successfully extracted to produce high purity and to include the type of HMP. Orodispersible film DH has been made and has met compendial standard parameters as they showed to have disintegration time of 48.5-59 seconds, a tensile strength of 20.59-32.45 kg/cm2, and elongation of 38.8-44%. The results showed that the increasing concentration of  Citrus maxima  pectin will accelerate the disintegration time, increase the elongation, and decrease the tensile strength.

Citrus maxima Pectin as Superdisintegrant: Preparation and Evaluation of Dextromethorphan Hydrobromide Orodispersible Film