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The study of search the bioactive compound from Indonesian Marine Sponge  Petrosia  sp. has been conducted on February 2019. The bioactive compound isolated based on bioassay-guided separation with several steps of chromatography. The compound known as C 16 H 25 NS determined by lCmS-ESI with molecular weight [M+H]+263.42m/z. The FTIR data showed that the functionality as hydrocarbon skeletone of alkane and isonitrile at 2982.58 cm −1  and 2115 cm −1 , respectively. Furthermore, the NMR data confirm that the active compound knowns as 4-amorphene-10- isothiocyanate. The cytotoxic data indicate that the bioactive compound has activity against Panc-1 cell [IC 50  = 0.1 μg / mL].The secondary metabolite from Indonesian marine sponge of  Petrosia  sp. has potential activity against human pancreatic cancer cells.

A marine isonitrile produced by Indonesian marine sponge of Petrosia sp. as an inhibitor of the human pancreatic cancer cells