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This article preliminarily revealed the mechanism of andrographolide (AD) nanoemulsifying inhibiting gastric cancer(GC). The targets of AD was searched by TCMSP and SwissTargetPrediction database, we entered the keyword “Gastric Cancer” in GeneCards database to find all targets related to GC. The intersection of AD and GC is taken as an important targets for AD to act on GC, Cytoscape 3.7.1 was used for topological analysis of the target, so as to obtain all important targets for AD to inhibit GC. DAVID database was used to perform biological process analysis on all potential targets, mainly through its analysis function. It involves Cell composition, molecular function and signal pathway enrichment analysis. Finally, we obtained a total of 53 potential targets related to GC, among which IL6, MAPK8, CREBBP, CDK2, MAPK14, AR and MAP2K1 may be important targets for inhibiting GC. The effect of AD on GC is mainly through Influenza A, Pathways in cancer, Sphingolipid signaling pathway, Progesterone-mediated oocyte maturation, Herpes simplex infection and other important pathways which are closely related to 10 biological processes such as protein phosphorylation, signal transduction, peptidyl-serine phosphorylation, positive regulation of gene expression, and positive regulation of transcription from RNA polymerase II promoter Sex. This study can provide guidance for the development of anti-GC drugs.

An Exploration on Mechanisms of Andrographolide Nanoemulsifying in Treating Gastric Cancer Based on Network Pharmacology