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In recent years, it has been argued and shown experimentally that ion channel noise in neurons can cause fundamental effects on the neuron’s dynamical behavior. Most profoundly, ion channel noise was seen to be able to cause spontaneous firing and stochastic resonance. However, Hodgkin-Huxley model affected when inserting some colored noise terms inside the conductance’s, where those effects captured by colored noise due to the gate multiplicity. This paper presents a new ion channel model under time varying periodic input currents. It firstly introduced the effect of without, with (colored noise), on the proposed model and the comparison of ion channel based on HH, Fox- Lu, and Linaro models. Additionally, in order to overcome the limitations of other parameter estimation methods, the proposed method fully constraints their models and obtains all models capabilities of reproducing the data. Finally, the relationship between the sequence of colored noise and the spike frequency are simulated efficiently each gate compared with microscopic simulations of the stochastic Markov process method. The simulation results revealed that above a critical value of the input frequency and also below a certain amplitude value, the colored terms play a very prominent role on the firing statistics. In addition, the spiking rate generated from the proposed model very close to microscopic simulations and doesn’t effect by the membrane size.

A New Neuron Ion Channel Model Under Time Varying Input Currents