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One of efforts to improve quality of human resources in 21 st  century is improve the level of education quality by promoting a new curriculum that is 2013 curriculum. 2013 curriculum adheres to the basic view that learning is not merely a transfer of knowledge and ability, but also to build HOTS of learners. The study aims to find out effectiveness of students worksheets based guided inquiry on acid base material to improve students HOTS. Type of research is quasi experiments with design non-equivalent control class. sampling techniques using cluster purposive sampling. The sample was 127 students consisting of two schools are SMAN 4 Padang and SMAN 8 Padang. Experimental class 1 (n=32 students) and control class 1 (n=32 students) came from SMAN 4 Padang. Experimental Class 2 (n=33 students) and control 2 (n=30 students) came from SMAN 8 Padang. The experimental class used a student worksheets based guided inquiry, while control class used textbooks available at school. Result of this research shows experimental class 1 and control class 1 got N-gain score are 0.64 and 0.58, while experiment class 2 and control class 2 got N-gain score are 0.60 and 0.56 both groups proved to have statistically significant different improvement. It means student worksheets based guided inquiry are increase HOTS students.

Effectiveness of student worksheets based guided inquiry on acid base material to improve students higher order thinking skill (HOTS)