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In-silico study of kaempferol has been performed to determine its potential as a natural estrogen competitor in an effort to suppress the growth of endometrial cancer. This study used a method of molecular decelerating of kaempferol against estrogen receptor alpha, which is compared with natural estrogen in the body. The research process was conducted at the Laboratory of Biology Department of Science and Technology Faculty of UIN Sunan Gunung Djati Bandung, from December 2017 until February 2018. The software used in this study is PyRx-Virtual Screening Tools (for molecular docking process) and Discovery Studio (for pose visualization and data analysis). The results showed that kaempferol is a potential natural estrogen competitor. It is indicated by the lower binding affinity value of kaempferol (-7.0 kcal/mol) than the binding affinity of natural estrogen (-6.7 kcal/mol). The low-affinity binding value shows a stable interaction. This means that Kaempferol is a potential phytoestrogen for cancer therapy without side effects.

In silico analysis of kaempferol as a competitor of estrogen on estrogen receptor alpha of endometrial cancer